User: Kevinn011

Logically, yes, there is cross-tolerance. MDMA and 3MMC both interact with serotonin. If you use 3MMC regularly for three months, don’t expect the same unique experience as your first time with MDMA.

User: musteatyourgreens

This is incorrect.

• 3MMC affects serotonin differently: 3MMC releases serotonin, whereas MDMA primarily releases serotonin.

• Primary effects: 3MMC mainly affects dopamine, while MDMA primarily affects serotonin.

• Frequency of use: 3MMC can be used more frequently than MDMA. The real concern with 3MMC is its tendency to cause compulsive redosing.

User: Kevinn011

Are you saying I can use 3MMC and still have an excellent MDMA experience every three months? That’s not realistic. MDMA and 3MMC have cross-tolerance. Even though 3MMC primarily works with dopamine, it still affects serotonin.

User: musteatyourgreens

Every stimulant has some cross-tolerance, but the degree depends on the substance. For example:

• 4MMC and MDMA have more cross-tolerance than 3MMC and MDMA because 4MMC is more serotonergic.

• Using 3MMC during your 3-month MDMA cycles is generally fine.

User: Kevinn011

Interesting, but it doesn’t work for me. If I use 3MMC a few weeks before MDMA, the MDMA experience feels weaker. I only use pure, tested substances (no pills).

User: prodavion

Most people can still have a great MDMA experience even after using 3MMC. The cross-tolerance isn’t strong enough to ruin the experience. I’ve taken MDMA three days in a row and still had amazing experiences each time.

User: Dull_Banana_7937

This might also be incorrect. 3MMC increases both serotonin and dopamine, with serotonin levels similar to MDMA. Therefore, MDMA and 3MMC should be used with similar frequency. 3MMC is dangerous due to its rapid craving effects.

User: musteatyourgreens (Edited)

Regarding 3MMC:

• It releases less serotonin than MDMA and doesn’t produce neurotoxic metabolites.

• 3MMC acts more on dopamine than serotonin, with a DAT:SERT ratio favoring dopamine.

Source: WHO review report on 3MMC.

User: Kuzcou

Yes, there is cross-tolerance.

User: Niyak36

3MMC affects serotonin too? No wonder the pills don’t work like they used to.

User: Kevinn011

Of course! 🙂

User: [deleted]

Be careful—many substances sold as 3MMC are actually 3CMC, which is more toxic. Always test your substances.

User: Kevinn011

There’s no real 3MMC left. I checked four dealers and had samples tested. If you think you have 3MMC, get it lab-tested. Soon, even 3CMC will be gone, leaving only 2MMC, which has no euphoria and acts like speed.

Key Takeaways

1. Cross-Tolerance: MDMA and 3MMC have some degree of cross-tolerance due to their effects on serotonin and dopamine.

2. Differences in Mechanism:

   • 3MMC releases serotonin and dopamine but is more dopaminergic.

   • MDMA primarily releases serotonin.

3. Frequency of Use: 3MMC can be used more frequently than MDMA, but it carries risks of compulsive use.

4. Substance Purity: Many substances sold as 3MMC may actually be 3CMC or other analogs, which can be more toxic. Always test your substances.

Discussion: Mixing MDMA and 3MMC

This is a curated discussion from Reddit users about the effects and risks of combining MDMA and 3MMC. The conversation explores whether mixing these substances can replicate the effects of 4MMC and highlights potential risks and experiences.

Original Post

User: ChainHuge686
Thinking of combining the two for hopefully getting closer to the 4MMC feeling. Planning to take 3 medium-high doses of 3MMC and 100mg MDMA with a 60mg redose later on. I’ve read that cocaine can kill the MDMA high—should I be worried about the same with 3MMC? Your thoughts and/or experiences?

User: whattheactualfuck420

I don’t know about killing the high, but combining uppers like 3MMC with MDMA increases the risk of heart and blood pressure issues. Personally, I wouldn’t risk it.

User: Fluffy_Coffee_8776

I recommend taking half the amount of MDMA. Start with a small dose (40-60mg) to get a warm, open feeling without rolling too hard. Then, add 3MMC in small bumps to enhance the euphoria. If you take too much MDMA initially, the 3MMC might feel overwhelming.

User: DishSuch3144

I’ve mixed 3MMC and MDMA, and they go well together in my opinion. One line of 3MMC can keep you good for up to 3 hours.

User: ChainHuge686 (OP)

Interesting. It seemed underwhelming to me a year ago, but maybe the MDMA pill was underdosed, and the 3MMC was poor quality or possibly 3CMC.

User: DishSuch3144

Yeah, 3CMC is bottom-of-the-barrel stuff. At a 9-hour rave, I usually consume around 300mg MDMA and half a gram of 4MMC, but I’m also a larger person (198cm, 100kg).

User: Responsible-Spot4663

Your plan might work, but the 3MMC could get lost in the effects of the MDMA. Back when MDMA was purer, I found that adding cocaine during the roll didn’t do much—it was better for the comedown or early in the night.

If you’re after the 4MMC feeling, why not just take 4MMC? Is it harder to find where you are?

User: Final-Election-4747

I’d never recommend mixing two stimulants. While they share some effects, their different properties can lead to bad reactions.

User: SquashInteresting283

Your heart won’t thank you for mixing these.

Key Takeaways

1. Combining MDMA and 3MMC:

   • Some users report that the combination works well, with 3MMC enhancing the euphoria of MDMA.

   • Others warn that the 3MMC might feel underwhelming if the MDMA dose is too high.

2. Risks:

   • Mixing stimulants like MDMA and 3MMC increases the risk of heart and blood pressure issues.

   • Compulsive redosing and overstimulation are potential dangers.

3. Dosage Advice:

   • Start with a lower dose of MDMA (40-60mg) to avoid overwhelming effects when adding 3MMC.

   • Use 3MMC in small bumps to gauge its impact.

4. Quality Concerns:

   • Ensure your substances are pure and tested. Many 3MMC products are actually 3CMC, which is less euphoric and potentially more toxic.

Discussion: Do 4MMC and Similar Drugs Deplete Serotonin Like MDMA?

This is a curated discussion from Reddit users about whether 4MMC, 3MMC, 4CMC, and 3CMC deplete serotonin levels similarly to MDMA. The conversation also touches on hangovers, addiction, and the safety of these substances.

Original Post

User: Flat_Big8841
Does 4MMC and similar drugs like 3MMC, 4CMC, and 3CMC deplete your serotonin like MDMA does? I’ve heard that MDMA alters serotonin levels for up to two weeks and can cause depression. Do 4MMC and similar drugs have the same effect?

User: AlPacyno

• 4MMC releases more serotonin than MDMA.

• 3CMC depletes less serotonin than 4MMC.

• 4CMC releases more serotonin than 3CMC but less than 4MMC. (Note: 4CMC is more toxic and should be avoided.)

Yes, you should wait at least a month between uses. Personally, 4MMC gives me a hangover, and I feel sad for about three days (similar to “Suicide Tuesday” with MDMA). With 3CMC, I don’t experience this because it has little serotonin action.

User: Flat_Big8841 (OP)

I’ve taken something sold as 4MMC once and didn’t experience a hangover or negative effects. At first, I didn’t think about taking it again, but after a month, I’m considering it. Am I already addicted? People wait three months to take MDMA again.

Are you addicted? How often do you take it, and when did you start?

User: Savings_Piglet9189

What do you think of 2MMC? I ordered it once and didn’t feel anything except a faster heartbeat.

On the other hand, NEP is really great, and 4FMA is good too, though it has a disgusting smell and taste.

User: olekdxm

4MMC gives me an afterglow.

Key Takeaways

1. Serotonin Depletion:

   • 4MMC releases more serotonin than MDMA and can cause significant serotonin depletion, leading to hangovers and mood dips.

   • 3CMC has less serotonin activity and is less likely to cause hangovers or mood changes.

   • 4CMC is more toxic and should be avoided despite its serotonin-releasing effects.

2. Frequency of Use:

   • Wait at least one month between uses of 4MMC to minimize serotonin depletion and negative aftereffects.

   • Unlike MDMA, which requires a 3-month break, 4MMC and similar drugs may have shorter recovery times, but caution is still advised.

3. Addiction Potential:

   • The desire to use 4MMC again after a month may indicate psychological dependence, especially if the substance was enjoyable.

   • Addiction risks vary by individual, but frequent use of serotonin-releasing drugs can lead to compulsive behavior.

4. Other Substances:

   • 2MMC is reported to have minimal effects, while NEP and 4FMA are considered more effective but come with their own risks and side effects.

Discussion: Smoking 6-APB – Advice and Risks

This is a curated discussion from Reddit users about the feasibility and risks of smoking 6-APB. The conversation highlights why smoking 6-APB is generally discouraged and offers safer alternatives.

Original Post

User: [deleted]
I want to try smoking 6-APB on foil. I have 140mg of 6-APB. My questions are:

1. How do I smoke it properly? (I’ve never used foil before.)

2. Should I split it into two doses of 70mg each, or can I smoke it all at once?

3. Any tips on how to cook it on foil?

Thanks in advance!

User: Flubroclamchowder

Don’t do it. Almost all 6-APB is in fumarate form, which is horrible for your lungs when smoked. The vapor is caustic, tastes awful, and will make you cough intensely. If you want a faster-acting ROA (route of administration), consider boofing or snorting 5-MAPB HCl instead.

User: [deleted]

I know oral is better, but I just want to try smoking it once. If smoked correctly, will I get high, or will it be underwhelming?

User: Flubroclamchowder

There’s no “correct” way to smoke 6-APB. It will damage your lungs no matter what. The only safe and effective way to use 6-APB is orally.

User: [deleted]

My reasoning was that smoking would make the high more intense but shorter in duration. I’m going to try it anyway for science. Thanks, bro.

User: Flubroclamchowder

I strongly advise against it, but I can’t stop you. If you want a shorter-lasting experience, try 5-MAPB instead. It’s often available in HCl form, which can be snorted or boofed.

User: [deleted]

The worst that could happen is I won’t feel anything. I actually have 5-MAPB, but I don’t like it unless I combine it with an LSD analog. Thanks, bro.

User: olekdxm

You can smoke 5-MAPB, but not 6-APB.

Key Takeaways

1. Smoking 6-APB is Not Recommended:

   • Most 6-APB is in fumarate form, which produces caustic vapor that can severely irritate your lungs.

   • Smoking 6-APB is unlikely to provide a pleasant or effective high and may cause harm.

2. Safer Alternatives:

   • Use 6-APB orally for a safer and more predictable experience.

   • Consider 5-MAPB (in HCl form) for a shorter-lasting high. It can be snorted or boofed, but smoking is still not ideal.

3. Dosage Advice:

   • If using 6-APB orally, a typical dose ranges from 70mg to 140mg, depending on tolerance and desired effects.

   • Splitting the dose into two smaller amounts (e.g., 70mg each) can help manage intensity and duration.

4. Harm Reduction:

   • Avoid experimenting with unproven ROAs like smoking, especially with substances not designed for inhalation.

   • Always prioritize safety and research before trying new methods of consumption.

Original Post

User: [deleted]
I’ve seen many posts about combining 6-APB with 4-HO-MET, but would a small dose (5mg or less) of AMT work well with 6-APB? Has anyone successfully combined the two?

User: TrippinEliminster

AMT is amazing on its own, but I would not recommend combining it with 6-APB or any other stimulant or serotoninergic drug. Both substances affect similar parts of the brain, so if you do decide to mix them, proceed with extreme caution and start with very low doses.

User: MineCamo

AMT has MAOI properties, which makes combining it with serotoninergic releasers/reuptake inhibitors like 6-APB extremely risky. The interactions are unpredictable and could lead to serotonin syndrome, a potentially life-threatening condition. The potential high is not worth the danger.

User: Either-City2775

I once combined AMT with 4-HO-MiPT, 1cP-AL-LAD, 1D-LSD, a bit of NEP and 4MPD, and topped it off with 5-MAPB and 6-APB. I also smoked weed during the experience. It was one of the most intense and amazing trips of my life!

User: ekuoJ

Bro, wtf? All of that in one day? You’re crazy—calm down, man.

User: Either-City2775

I knew what I was doing. I took everything one at a time in small doses. The experience lasted through the night and into the next day. By the afternoon, I was still seeing hieroglyphs instead of text on my phone. Petting my rabbit, I could see energy swirling from my hand and mixing with its fur and aura. It was magical and unforgettable. AMT is like the MDMA of tryptamines—intense, beautiful, and mystical.

Key Takeaways

1. Risks of Combining AMT and 6-APB:

   • AMT has MAOI properties, which can dangerously increase serotonin levels when combined with serotoninergic drugs like 6-APB.

   • This combination significantly raises the risk of serotonin syndrome, a potentially fatal condition.

2. Harm Reduction Advice:

   • Avoid mixing AMT with 6-APB or any other serotoninergic substances.

   • If you still choose to experiment, start with very low doses and proceed with extreme caution.

3. Personal Experiences:

   • Some users report intense and magical experiences when combining AMT with other psychedelics and stimulants, but these combinations are highly unpredictable and risky.

   • AMT is often described as the MDMA of tryptamines due to its intense and euphoric effects.

4. General Caution:

   • Combining multiple substances, especially those affecting serotonin, is inherently dangerous and should be avoided unless you are highly experienced and understand the risks.